期刊
CELL CYCLE
卷 5, 期 12, 页码 1265-1268出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.12.2834
关键词
ATR; TopBP1; ATRIP; DNA replication checkpoint; DNA damage
类别
资金
- NIGMS NIH HHS [GM070891] Funding Source: Medline
ATR is a critical upstream regulator of checkpoint responses to incompletely replicated and damaged DNA. However, it had not been understood how the kinase activity of ATR is switched on during checkpoint responses. TopBP1 and its homologs are necessary for both DNA replication and checkpoint control. A recent report from this laboratory demonstrated that TopBP1 functions as an activator of ATR. It had been known that TopBP1 accumulates at sites of replicative stress and DNA damage. Thus, interaction of ATR with a critical protein at stalled replication forks and sites of DNA damage triggers its activation. This finding helps to explain how aberrant DNA structures in the genome induce ATR-dependent signaling processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据