Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton. (c) 2006 Elsevier Ltd. All rights reserved.