期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 12, 页码 4227-4240出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.01.068
关键词
antibacterials; oxazolidinones; structure-activity relationships; protein synthesis inhibitors
The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and structure-activity relationships (SAR) are discussed in the context of earlier work in the field. Key issues of potency, spectrum, selectivity, in vivo efficacy, and pharmacokinetic profile of the new analogs are addressed. (c) 2006 Elsevier Ltd. All rights reserved.
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