期刊
ANNALS OF NUTRITION AND METABOLISM
卷 62, 期 4, 页码 311-322出版社
KARGER
DOI: 10.1159/000346968
关键词
Bioavailability; EURRECA; Nutritional requirements; Recommended dietary allowances; Review; Vitamin B12
资金
- Commission of the European Communities, a specific research, technology and development program Quality of Life and Management of Living Resources, within the Sixth Framework Program [036196]
Aims: To systematically review the literature on daily losses and bioavailability of vitamin B12. These estimates could be used for deriving recommendations on vitamin B12 intake for adults and elderly. Methods: We identified publications on daily vitamin B12 losses (July 2011) and publications on the bioavailability of vitamin B12 from foods or diets (June 2010) in MEDLINE, EMBASE and the Cochrane Library. Results: A pooled analysis of five studies (52 subjects) showed that 0.13 +/- 0.03% of the total body store is lost per day. Absorption of vitamin B12 ranged from 4.5 (dose of 38 mu g from consumption of liver) to 83% (dose of 3.0 mu g from consumption of mutton meat). Data from eight studies including 83 subjects suggested that the amount of vitamin B12 absorbed from food (A(i)) increased with increasing doses of vitamin B12 (D-i) as described by the equation: ln(A(i)) = 0.7694 * ln(D-i) - 0.9614. Conclusion: Daily vitamin B12 losses in apparently healthy adults and elderly probably range from 1.4 to 5.1 mu g. Vitamin B12 intakes needed to compensate for these losses seem to range from 3.8 to 20.7 mu g. More evidence is needed on the relationships between biochemical markers of vitamin B12 status, vitamin B12 body store and long-term health outcomes to evaluate whether current recommendations on vitamin B12 intake (1.4-3 mu g) need to be changed. Copyright (c) 2013 S. Karger AG, Basel
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