期刊
SCIENCE
卷 312, 期 5780, 页码 1672-1676出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1125703
关键词
-
资金
- Intramural NIH HHS Funding Source: Medline
In contrast to naive T cells that recognize short antigen-derived peptides displayed by specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily recognize intact proteins. How and where within a lymph node such unprocessed antigens become available for naive B cell recognition is not clear. We used two-photon intravital imaging to show that, after exiting high-endothelial venules and before entry into lymph node follicles, B cells survey locally concentrated dendritic cells. Engagement of the B cell receptor by the dendritic cell (DC)-associated antigen leads to lymphocyte calcium signaling, migration arrest, antigen acquisition, and extrafollicular accumulation. These findings suggest a possible role for antigen-specific B-DC interactions in promoting T cell - dependent antibody responses in vivo.
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