期刊
ANNALS OF NUTRITION AND METABOLISM
卷 61, 期 1, 页码 15-24出版社
KARGER
DOI: 10.1159/000338634
关键词
Resveratrol; Catechin; Grape seed extract; Oxidative stress; Gene expression; Microarray
Background: The preventive effect of resveratrol (RES) on the development of human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative of RES in which phosphate groups protect the phenolic groups. Aims: This study compared the effect of RIP on biochemical and molecular markers of oxidative stress to equimolar doses (0.66 mmol) of RES and catechin-rich grape seed extract (CGSE) in a model of oxidative and metabolic stress associated with obesity in humans. Methods:Thirty-two obese subjects (BMI between 30 and 40) were enrolled. They all received 1 capsule of placebo/day for 28 days before being randomly devised into three arms receiving 1 capsule/day of RES, CGSE, or RIP during the following consecutive 28 days. Blood samples were collected at baseline, after the end of placebo intake, and after the end of the investigational product intake. Biochemical parameters of oxidative stress and blood expression of 200 redox-related genes were determined at each time point. Results: RTP and CGSE showed better antioxidant activities compared to RES and induced important modulations of gene expression. Conclusion: The results suggest that RIP and CGSE could contribute to a significant reduction of oxidative stress in obese subjects. Copyright (C) 2012 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据