期刊
CANCER LETTERS
卷 237, 期 2, 页码 289-297出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.06.009
关键词
reversion-inducing cysteine-rich protein with kazal motifs extracellular matrix metalloproteinase inducer; matrix metalloproteinase; gelatinase; survival analysis
类别
mRNA, and latent and active levels MMP-2 and -9 were higher in tumor tissue compared to normal tissue from 63 patients with colorectal cancer, whereas RECK and EMMPRIN levels were lower. Correlations between mRNA, latent, and active MMP were particular high for MMP-2 in tumor tissue (R-8 = 0.6-0.8. P < 0.001). For active MMP-2, but not for MMP-9, a significant negative partial correlation (R-p = -0.440, P < 0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P = 0.017) association with overall survival. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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