期刊
TETRAHEDRON
卷 62, 期 25, 页码 5922-5930出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.04.021
关键词
Ugi reaction; multicomponent reaction; imine; amino acid; isocyanide; proline; homoproline; peptide
The Ugi three-component reaction with 2-substituted five-, six-, and seven-membered cyclic imines was investigated. The reaction opens a new route to substituted proline and homoproline derivatives. It was shown that the method is efficient for the one-step preparation of seminatural dipeptides containing natural amino acid residues, and fragments of substituted proline or pipecolinic acid. The scope and limitation of the approach are discussed. (c) 2006 Elsevier Ltd. All rights reserved.
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