期刊
TETRAHEDRON LETTERS
卷 47, 期 25, 页码 4253-4257出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.04.025
关键词
pyrrolo[2,1-c][1,4]benzodiazepines; solid-phase synthesis; boron trifluoride diethyletherate; resin cleavage; reductive cyclization
An efficient method for the reduction of aromatic azides in both solution and solid-phase has been developed by employing (BF3OEt2)-O-./EtSH. This report also describes resin cleavage employing this reagent system. Further, this protocol has been utilized for the solution as well as the solid-phase synthesis of pyrrolo[2, 1-c][1,4]benzodiazepines, including the naturally occurring antibiotic DC-81 and fused [2,1-b]quinazolinones. (c) 2006 Elsevier Ltd. All rights reserved.
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