期刊
ANNALS OF NUTRITION AND METABOLISM
卷 58, 期 1, 页码 68-73出版社
KARGER
DOI: 10.1159/000325537
关键词
Serum folate; Plasma cysteine; Plasma homocysteine; Serum triglycerides; Industry workers
资金
- MRC [MC_U105960384] Funding Source: UKRI
- Medical Research Council [MC_U105960384] Funding Source: researchfish
- Medical Research Council [MC_U105960384] Funding Source: Medline
Background: A low concentration of serum folate is associated with an increased risk of cardiovascular disease. Extracellular cysteine is involved in aging, cancer and cardiovascular disease. The relationship between serum folate and plasma cysteine is poorly understood. Therefore, we investigated this relationship in industry workers, whose health has economic implications. Methods: The concentration of serum folate was determined by the Access ImmunoAssay System Sanofi Pasteur. Plasma cysteine and homocysteine were measured by an ion-pair HPLC method. The concentrations of serum triglycerides were determined by an enzymatic colorimetric method. Results: We detected a positive correlation between the concentration of serum folate and plasma cysteine, whereas the concentration of serum folate was negatively correlated with plasma homocysteine and serum triglycerides. In a multiple regression analysis with adjustment for age, BMI and smoking, serum folate as the dependent variable exhibited a strong relationship with plasma cysteine, and a negative relationship with plasma homocysteine and serum triglycerides. Conclusion: We observed significant correlations between serum folate, plasma cysteine and serum triglyceride concentrations in industry workers, implying that folate may modulate key aspects of the body's cysteine and lipid metabolism. Copyright (C) 2011 S. Karger AG, Basel
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