期刊
BIOPHYSICAL CHEMISTRY
卷 122, 期 1, 页码 1-4出版社
ELSEVIER
DOI: 10.1016/j.bpc.2006.01.003
关键词
human leukemia cells; magnetic force microscopy; morphologic image; magnetic image; antisense oligonucleotides; apoptosis
Magnetic force microscopy (MFM) has been employed to observe antisense oligonucleotides (ASOs)-coupled silica-coated magnetic iron oxide nanoparticles (SMNPs) internalized into human leukemia (HL-60) cells. The experiment demonstrated that the ASOs-coupled SMNPs delivery into the cells really occurred. The nanoparticles were internalized into the cells and the apoptotic topography can be directly visualized simultaneously with MFM technology. These present observations offer direct morphology evidence on studying the apoptosis of tumor cells and provide useful information for better design of new diagnostic and therapeutic tools in tumor treatment. (c) 2006 Elsevier B.V. All rights reserved.
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