期刊
ANNALS OF NUTRITION AND METABOLISM
卷 54, 期 3, 页码 184-188出版社
KARGER
DOI: 10.1159/000217815
关键词
Colonic restriction; Fasting; Mood; Genotype; GNB3 C825T polymorphism
Background/Aims: The 825T allele of the G protein beta 3-subunit gene (GNB3) is a thrifty genotype associated with an increased risk for obesity. We aimed to determine whether the 825T allele is modifying the subjective response to extended fasting. Methods: We genotyped 108 subjects who underwent an 8-day modified medical fasting treatment [total energy intake <350 kcal (1465 kJ)/day] for the GNB3 C825T polymorphism. Perceived hunger and mood were recorded daily by self-rating visual analogue scales. Results: Whereas weight loss was not dependent on genotype, both mood and hunger were significantly associated with genotype, with homozygous CC genotype carriers having best mood (p = 0.004) and least hunger (p = 0.036) during fasting compared to TT genotype carriers. Conclusions: Pronounced mental discomfort during fasting in 825T allele carriers might partly explain their increased risk for obesity. The strong association between the subjective response to fasting with GNB3 genotypes indicates a role of the gene in the behavioural regulation of food intake, which should be further considered in nutritional intervention studies. Copyright (C) 2009 S. Karger AG, Basel
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