期刊
JOURNAL OF NEUROSCIENCE
卷 26, 期 25, 页码 6885-6892出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1062-06.2006
关键词
accumbens; adolescent; reward; development; orbital frontal cortex; risk-taking
资金
- NEI NIH HHS [T32 EY07138] Funding Source: Medline
- NIDA NIH HHS [R21 DA15882, R01 DA18879] Funding Source: Medline
- NIMH NIH HHS [P50 MH62196] Funding Source: Medline
Adolescence has been characterized by risk-taking behaviors that can lead to fatal outcomes. This study examined the neurobiological development of neural systems implicated in reward-seeking behaviors. Thirty-seven participants (7-29 years of age) were scanned using event-related functional magnetic resonance imaging and a paradigm that parametrically manipulated reward values. The results show exaggerated accumbens activity, relative to prefrontal activity in adolescents, compared with children and adults, which appeared to be driven by different time courses of development for these regions. Accumbens activity in adolescents looked like that of adults in both extent of activity and sensitivity to reward values, although the magnitude of activity was exaggerated. In contrast, the extent of orbital frontal cortex activity in adolescents looked more like that of children than adults, with less focal patterns of activity. These findings suggest that maturing subcortical systems become disproportionately activated relative to later maturing top-down control systems, biasing the adolescent's action toward immediate over long-term gains.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据