期刊
ORGANIC LETTERS
卷 8, 期 13, 页码 2783-2785出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol060856u
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资金
- NIGMS NIH HHS [GM 36792] Funding Source: Medline
(+)-Epolactaene was synthesized in 14 steps in the longest linear sequence. The synthesis is highlighted by a highly efficient preparation of the lactone intermediate 4, which only requires three steps from the commercially available (S)-3-butyn-2-ol. It also features a fully stereocontrolled synthesis of the intermediate 9, which was constructed through the use of Zr-catalyzed methylalumination of alkynes and a series of Pd-catalyzed organozinc cross-coupling reactions, such as homopropargylation, direct ethynylation, and alkenylation of the methyl ester of (Z)-alpha-iodocrotonic acid (3).
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