期刊
NATURE
卷 441, 期 7096, 页码 988-991出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature04813
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资金
- Medical Research Council [G0401620] Funding Source: Medline
- MRC [G0401620] Funding Source: UKRI
- Medical Research Council [G0401620] Funding Source: researchfish
The thymus provides an essential environment for the development of T cells from haemopoietic progenitors. This environment is separated into cortical and medullary regions, each containing functionally distinct epithelial populations that are important at successive stages of T-cell development and selection(1,2). However, the developmental origin and lineage relationships between cortical and medullary epithelial cell types remain controversial(3). Here we describe a clonal assay to investigate the developmental potential of single, individually selected, thymic epithelial progenitors ( marked with enhanced yellow fluorescent protein) developing within the normal architecture of the thymus. Using this approach, we show that cortical and medullary epithelial cells share a common origin in bipotent precursors, providing definitive evidence that they have a single rather than dual germ layer origin during embryogenesis. Our findings resolve a long-standing issue in thymus development, and are important in relation to the development of cell-based strategies for thymus disorders and the possibility of restoring function of the atrophied adult thymus.
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