期刊
SCIENCE
卷 312, 期 5781, 页码 1791-1795出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1127981
关键词
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资金
- NCRR NIH HHS [RR17573] Funding Source: Medline
Bacteriophages, herpesviruses, and other large double-stranded DNA (dsDNA) viruses contain molecular machines that pump DNA into preassembled procapsids, generating internal capsid pressures exceeding, by 10-fold, that of bottled champagne. A 17 angstrom resolution asymmetric reconstruction of the infectious P22 virion reveals that tightly spooled DNA about the portal dodecamer forces a conformation that is significantly different from that observed in isolated portals assembled from ectopically expressed protein. We propose that the tight dsDNA spooling activates the switch that signals the headful chromosome packing density to the particle exterior.
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