期刊
FEBS LETTERS
卷 580, 期 15, 页码 3726-3730出版社
WILEY
DOI: 10.1016/j.febslet.2006.05.046
关键词
DNA; DNA sequence selectivity; ligand-DNA interactions; thermodynamics; DNA meltings; circular dichroism
Different DNA selectivity was found for the newly synthesized europium-L-valine complex. Unexpected DNA and RNA selection results showed that europium-L-valine complex can cause single-stranded polydA and polyrA to self-structure. The sigmoidal melting curve profiles indicate the transition is cooperative, similar to the cooperative melting of a duplex DNA. This is different from another europium amino acid complex, europium-L-aspartic acid complex which can induce B-Z transition under the low salt condition. To our knowledge, there is no report to show that a metal-amino acid complex can cause the self-structuring of single-stranded DNA and RNA. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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