期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 252, 期 1-2, 页码 102-106出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2006.03.009
关键词
ovarian follicles; meiosis; oocyte; gap junctions; Connexin 43
The source of the inhibitory levels of cAMP that maintain oocytes meiotically arrested is under controversy. A model for regulation of the meiotic division that suggests the transfer of a somatic follicular cells-derived cAMP into the oocyte via gap junctions was first proposed by us in 1978. Later studies provide strong evidence that established gap-junctional communication within the ovarian follicle is indispensable for maintenance of meiotic arrest. On the other hand, other recent reports suggest that oocytes generate their own inhibitory cAMP by a G protein-coupled receptor-activated Gs. These studies as well as other recent reports related to this topic are thoroughly discussed in this chapter. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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