期刊
VACCINE
卷 24, 期 26, 页码 5434-5441出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.03.054
关键词
mucosal vaccine; Lactococcus lactis; gram-positive enhancer matrix (GEM); Streptococcus pneumoniae; SlrA; PpmA; IgA1 protease
The present work reports the use of non-living non-recombinant bacteria as a delivery system for mucosal vaccination. Antigens are bound to the cell-wall of pretreated Lactococcus lactis, designated as Gram-positive enhancer matrix (GEM), by means of a peptidoglycan binding domain. The influence of the GEM particles on the antigen-specific serum antibody response was studied. Following nasal immunization with the GEM-based vaccines, antibody responses were induced at systemic and local levels. Furthermore, different GEM-based vaccines could be used consecutively in the same mice without adverse effects or loss of activity. Taken together, the results evidence the adjuvant properties of the GEM particles and indicate that GEM-based vaccines can be used repeatedly and are particularly suitable for nasal immunization purposes. (c) 2006 Elsevier Ltd. All rights reserved.
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