期刊
CELL
卷 125, 期 7, 页码 1321-1332出版社
CELL PRESS
DOI: 10.1016/j.cell.2006.04.039
关键词
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资金
- NIGMS NIH HHS [R01 GM058673, R01 GM058673-07, R01 GM058673-06A1, R01 GM58673, R01 GM058673-08, R01 GM058673-09] Funding Source: Medline
Meiosis is a specialized cell division that halves the genome complement, producing haploid gametes/spores from diploid cells. Proper separation of homologous chromosomes at the first meiotic division requires the production of physical connections (chiasmata) between homologs through recombinational exchange of chromosome arms after sister-chromatid cohesion is established but before chromosome segregation takes place. The events of meiotic prophase must thus occur in a strictly temporal order, but the molecular controls coordinating these events have not been well elucidated. Here, we demonstrate that the budding yeast cyclin-dependent kinase Cdc28 directly regulates the formation of the DNA double-strand breaks that initiate recombination by phosphorylating the Mer2/Rec107 protein and thereby modulating interactions of Mer2 with other proteins required for break formation. We propose that this function of Cdc28 helps to coordinate the events of meiotic prophase with each other and with progression through prophase.
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