4.7 Article

An expanded and flexible form of the vacuolar ATPase membrane sector

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STRUCTURE
卷 14, 期 7, 页码 1149-1156

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CELL PRESS
DOI: 10.1016/j.str.2006.05.014

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  1. Wellcome Trust Funding Source: Medline

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The vacuolar ATPase integral membrane c-ring from Nephrops norvegicus occurs in paired complexes in a double membrane. Using cryo-electron microscopy and single particle image processing of 2D crystals, we have obtained a projection structure of the c-ring of N. norvegicus. The c-ring was found to be very flexible, most likely as a result of an expanded conformation of the c subunits. This structure may support a role for the vacuolar ATPase c-rings in membrane fusion.

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