期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 7, 期 7, 页码 505-516出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1962
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Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
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