期刊
DEVELOPMENTAL CELL
卷 11, 期 1, 页码 9-19出版社
CELL PRESS
DOI: 10.1016/j.devcel.2006.06.009
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资金
- NICHD NIH HHS [R01HD045789, R01HD04260] Funding Source: Medline
- NIDDK NIH HHS [R01DK072301] Funding Source: Medline
Cilia and flagella are found on the surface of a strikingly diverse range of cell types. These intriguing organelles, with their unique and highly adapted protein transport machinery, have been studied extensively in the context of cellular locomotion, sexual reproduction, or fluid propulsion. However, recent studies are beginning to show that in vertebrates particularly, cilia have been recruited to perform additional developmental and homeostatic roles. Here, we review advances in deciphering the functional components of cilia, and we explore emerging trends that implicate ciliary proteins in signal transduction and morphogenetic pathways.
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