期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 26, 期 4-6, 页码 875-889出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-006-9014-3
关键词
haplotype; dopamine transporter; cocaine; Parkinson's disease; PET; postmortem brain
资金
- NIDA NIH HHS [DA00280, DA 7092-01, DA09490-01, DA 06227] Funding Source: Medline
1. Individuals display significant differences in their levels of expression of the dopamine transporter (DAT; SLC6A3). These differences in DAT are strong candidates to contribute to individual differences in motor, mnemonic and reward functions. To identify cis-acting genetic mechanisms for these individual differences, we have sought variants in 5' aspects of the human DAT gene and identified the haplotypes that these variants define. 2. We report (i) significant relationships between 5' DAT haplotypes and human individual differences in ventral striatal DAT expression assessed it? vivo using [C-11] cocaine PET and (ii) apparent confirmation of these results in studies of DAT expression in postmortem striatum Using [H-3] carboxyflurotropane binding. 3. These observations support the idea that cis-acting variation in 5' aspects of the human DAT/SLC6A3 locus contributes to individual differences in levels of DAT expression in vivo. 5' DAT variation is thus a good candidate to contribute to individual differences in a number of human phenotypes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据