期刊
NEUROCHEMISTRY INTERNATIONAL
卷 49, 期 2, 页码 183-189出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2006.04.003
关键词
microglia; astrocyte; PPAR; cytokine; neuroinflammation
资金
- NINDS NIH HHS [NS042860, R01 NS042860, NS047546, P30 NS047546-02, R01 NS042860-04, P30 NS047546] Funding Source: Medline
Peroxisome proliferator-activated receptors (PPARs) play key roles in lipid metabolism and inflammation. Recent studies indicated that PPARs are also capable of modulating immune responses. Microglia and astrocytes are cells resident to the central nervous system (CNS) that function to protect against environmental insults including pathogens. However, following CNS inflammation, reactive gliosis occurs which is characterized by astrocyte hypertrophy and increased glial proliferation. Under such conditions, glia can become chronically activated and may contribute to the neuropathology associated with a variety of neuroinflammatory disorders including multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. A review of the role of PPAR agonists in modulating glial cell activation is presented. Included is a discussion of the molecular mechanisms of action of these PPAR agonists and the potential utility of these agents for the treatment of neuroinflammatory disorders. (c) 2006 Elsevier Ltd. All rights reserved.
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