期刊
TOXICOLOGICAL SCIENCES
卷 92, 期 1, 页码 219-227出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfj209
关键词
Parkinson's disease; secondary; manganese poisoning; pharmacokinetics; inhalation exposure; Macaca mulatta; magnetic resonance imaging
类别
High-dose manganese exposure is associated with parkinsonism. Because manganese is paramagnetic, its relative distribution within the brain can be examined using magnetic resonance imaging (MRI). Herein, we present the first comprehensive study to use MRI, pallidal index (PI), and T-1 relaxation rate (R1) in concert with chemical analysis to establish a direct association between MRI changes and pallidal manganese concentration in rhesus monkeys following subchronic inhalation of manganese sulfate (MnSO4). Monkeys exposed to MnSO4 at >= 0.06 mg Mn/m(3) developed increased manganese concentrations in the globus pallidus, putamen, olfactory epithelium, olfactory bulb, and cerebellum. Manganese concentrations within the olfactory system of the MnSO4-exposed monkeys demonstrated a decreasing rostralcaudal concentration gradient, a finding consistent with olfactory transport of inhaled manganese. Marked MRI signal hyperintensities were seen within the olfactory bulb and the globus pallidus; however, comparable changes could not be discerned in the intervening tissue. The R1 and PI were correlated with the pallidal manganese concentration. However, increases in white matter manganese concentrations in MnSO4-exposed monkeys confounded the PI measurement and may lead to underestimation of pallidal manganese accumulation. Our results indicate that the R1 can be used to estimate regional brain manganese concentrations and may be a reliable biomarker of occupational manganese exposure. To our knowledge, this study is the first to provide evidence of direct olfactory transport of an inhaled metal in a non-human primate. Pallidal delivery of manganese, however, likely arises primarily from systemic delivery and not directly from olfactory transport.
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