期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 36, 期 7, 页码 1753-1763出版社
WILEY
DOI: 10.1002/eji.200535492
关键词
CCL11; chemokine; eotaxin; intestinal nematode; Th2
类别
资金
- NIAID NIH HHS [AI45898] Funding Source: Medline
- Wellcome Trust [044494, 068028] Funding Source: Medline
Trichinella spiralis and Trichuris muris are nematode parasites of the mouse, dwelling in the small and large intestines, respectively: worm expulsion requires development of a Th2 immune response. The chemokine CCL11 is agonist for the chemokine receptor CCR3 and acts in synergy with IL-5 to recruit eosinophils to inflammatory sites. The role of CCL11 in gastrointestinal helminth infection has not been previously studied. We challenged wild-type (WT) BALB/c, CCL11 single knockout (SKO) and CCL11 IL-5 double knockout (DKO) mice with either T spiralis muscle larvae or T muris eggs in order to examine eosinophil recruitment to the small and large intestine during helminth infection. A peripheral eosinophilia was seen in WT and SKO mice during T spiralis infection but not with T muris. Gastrointestinal eosinophilia was markedly reduced but not ablated in SKO mice - and negligible in DKO mice - infected with either nematode. The residual eosinophilia and up-regulation of CCL24 mRNA in the gastrointestinal tract of SKO mice infected with either nematode, together with the presence of an eosinophil-active factor in T spiralis and T muris products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection.
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