期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 27, 期 2, 页码 180-192出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2006.02.001
关键词
neonatal; rat; human; stress; memory; hippocampus; corticotropin releasing hormone; CRF; hypothalamic pituitary adrenal axis; neuroplasticity
资金
- NIMH NIH HHS [R01 MH073136-05A1, R01 MH073136, NS39307/MH 73136] Funding Source: Medline
- NINDS NIH HHS [R01 NS039307, NS28912, R01 NS039307-04, R01 NS028912-10, R01 NS028912, R01 NS028912-09, R01 NS028912-11A2] Funding Source: Medline
Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons. (c) 2006 Elsevier Inc. All rights reserved.
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