期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 176, 期 1-2, 页码 76-85出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.04.008
关键词
orphanin FQ/nociceptin; staphylococcal enterotoxin A; cytokines
资金
- NIDA NIH HHS [DA141186] Funding Source: Medline
- NIEHS NIH HHS [P30 ES022, ES07148] Funding Source: Medline
- NIMH NIH HHS [MH060706] Funding Source: Medline
Orphanin FQ/nociceptin (OFQ/N) is a neuropeptide implicated in immunomodulation. Here, we show that endogenous and exogenous OFQ/N modulated the cytokine response to the bacterial superantigen staphylococcal enterotoxin A (SEA). Specifically, OFQ/N enhanced TNF alpha and IFN gamma transcripts in the spleen when injected prior to SEA challenge. Moreover, mice lacking the OFQ/N precursor gene showed diminished TNF alpha and IFN gamma mRNA induction in the spleen following SEA challenge. In addition, mRNA levels of ppOFQ/N and the OFQ/N receptor, NOP, were altered in thymus and spleen after SEA challenge. Overall, this suggests that the OFQ/N system can influence immune function and is itself influenced by immune stimuli. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据