期刊
GENES & DEVELOPMENT
卷 20, 期 13, 页码 1709-1714出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1434406
关键词
piRNA; gsRNA; spermatogenesis; sperniatid; mouse; MIWI
资金
- NCI NIH HHS [T32 CA59365, T32 CA059365] Funding Source: Medline
- NICHD NIH HHS [HD42012, R01 HD042012, R37 HD042012] Funding Source: Medline
Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of similar to 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs). piRNAs are similar to 30 nt in length. They are expressed during spermatogenesis, mostly in spermatids. piRNAs are associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, and depend on MIWI for their biogenesis and/or stability. Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation.
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