期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 134, 期 1, 页码 95-99出版社
WILEY
DOI: 10.1111/j.1365-2141.2006.06105.x
关键词
aplastic anaemia; cytogenetics; immunosuppressive therapy; prognosis; clonal complications
类别
The outcome of 81 adult aplastic anaemia patients who had successful cytogenetics at diagnosis and received immunosuppressive therapy was evaluated. Ten patients had an abnormal karyotype, six of which had a trisomy. Four of five evaluable patients with a trisomy responded. One patient with monosomy 7 achieved a complete response and later developed haemolytic paroxysmal nocturnal haemoglobinuria but no recurrence of monosomy 7. None of the patients with a non-numerical karyotypic abnormality responded. No significant differences in survival or later clonal disorders were observed between patients with a normal karyotype and those with an abnormal karyotype.
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