4.7 Article

A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity

期刊

PEDIATRICS
卷 118, 期 1, 页码 180-188

出版社

AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2005-2475

关键词

anemia of prematurity; erythropoietin; folic acid; vitamin B-12

向作者/读者索取更多资源

BACKGROUND. Premature infants, especially those with birth weights of < 1500 g, often suffer from anemia of prematurity and associated problems. Erythropoietin therapy is a safe effective way to prevent and to treat anemia of prematurity. We hypothesized that combined administration of vitamin B-12 and folate with erythropoietin and iron would enhance erythropoietin-induced erythropoiesis. METHODS. In a randomized, controlled trial, 64 premature infants ( birth weight: 801 - 1300 g) receiving erythropoietin and iron supplementation were assigned randomly to receive either vitamin B-12 ( 3 mu g/kg per day) and folate ( 100 mu g/kg per day) ( treatment group) or a lower dose of folate ( 60 mu g/kg per day) ( control group). RESULTS. During the 4-week observation period, vitamin B12 and folate enhanced erythropoietin-induced erythropoiesis significantly, as indicated by a 10% increase in red blood cell counts, compared with folate alone. Hemoglobin and hematocrit levels remained stable in the treatment group, whereas they decreased in the control group. Vitamin B12 levels in the treatment group increased over baseline and control values, whereas red blood cell folate levels were comparable between the groups. Subsequent analysis showed slight nonsignificant differences in baseline red blood cell count, hemoglobin level, hematocrit level, and mean corpuscular volume values, which must be addressed as a limitation. CONCLUSIONS. With the limitation of a slight imbalance in baseline data between the study groups, combined therapy with vitamin B12, folate, erythropoietin, and orally and intravenously administered iron seemed more effective in stimulating erythropoiesis among premature infants, compared with erythropoietin, iron, and low-dose folate alone. Additional trials are necessary to confirm these data.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据