期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 33, 期 -, 页码 S54-S63出版社
SPRINGER
DOI: 10.1007/s00259-006-0136-0
关键词
angiogenesis; radiolabelled RGD peptides; integrin alpha(v)beta(3); tracer techniques; molecular imaging
Overview: The field of angiogenesis research is one of the most rapidly growing biomedical disciplines. Great efforts are being made to develop anti-angiogenesis drugs for treatment of cancer as well as non-oncological diseases. Thus, imaging techniques allowing non-invasive monitoring of corresponding molecular processes will be of great interest. One target structure involved in the angiogenic process is the integrin alpha(v)beta(3), which mediates the migration of activated endothelial cells during vessel formation. Materials and methods: A variety of radiolabelled RGD peptides have been introduced for monitoring of alpha(v)beta(3) expression using nuclear medicine tracer techniques. Objectives: This review discusses tracer development and highlights some strategies for tracer optimisation. It summarises the preclinical and clinical data and discusses the potential of this class of tracer to characterise angiogenesis.
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