期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 116, 期 7, 页码 1767-1775出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI29027
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资金
- NIDDK NIH HHS [P01 DK56116, T32 DK007516, R01 DK060839, R01 DK60839, R01 DK43051, P30 DK057521, P30 DK57521, P01 DK056116, R01 DK043051, T32 DK07516] Funding Source: Medline
Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.
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