期刊
JOURNAL OF ANTIBIOTICS
卷 59, 期 7, 页码 428-431出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.60
关键词
awajanoran; Acremonium sp AWA16-1; dihydrobenzofuran; cytotoxic; antimicrobial
Awajanoran (1), a new dihydrobenzofuran derivative, was isolated from an agar-culture of Acremonium sp. AWA16-1, which had been isolated from sea mud collected at Awajishima Island in Japan. The structure of 1 was elucidated on the basis of a spectroscopic analysis. This compound inhibited the growth of A549 cells, the human lung adenocarcinoma cell line, with an IC50 value of 17 mu g/ml, and also showed antimicrobial activity.
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