期刊
LUNG CANCER
卷 53, 期 1, 页码 97-101出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2006.03.012
关键词
inflammatory mediators; non-small cell lung cancer; molecular biology; fibrinogen; C-reactive protein
Objectives: There is an association between coagulation and lung cancer. Therefore, preoperative plasma fibrinogen and serum C-reactive protein (CRP) concentration were assessed to determine their association with tumour characteristics and to ascertain any rote in patient selection for curative resection. Methods: These parameters were compared with tumour size, pTNM stage, and possibility of complete resection in 93 patients with non-small cell lung cancer who underwent surgical resection. Results: Plasma fibrinogen concentration (r(s)=0.34, P=0.001) and serum CRP concentration ((r(s)=0.34, P=0.001) were positively correlated with maximum pathological tumour size. A higher plasma fibrinogen concentration was associated with squamous cell carcinoma versus adenocarcinorna (4.5 +/- 0.13 g/L versus 3.6 +/- 0.28 g/L; P = 0.008), with a trend towards a similar association for CRP (P=0.06). Pathological T stage was also associated with mean plasma fibrinogen and serum CRP concentration (P=0.01 and 0.04, respectively), but pN stage was not associated with either parameter. Incomplete resection occurred in 23% of patients with plasma fibrinogen > 5 g/L or serum CRP > 40mg/L (versus only 8% when fibrinogen <= 5g/L and CRP <= 40 mg/L; P = 0.09). Conclusions: Plasma fibrinogen and serum CRP are associated with tumour characteristics. High values were associated with inability to achieve complete resection which may refine patient selection for thoracotomy when used with other staging modalities. Attempted resection may be justified in a patient of borderline fitness who has favourable plasma fibrinogen and serum CRP concentration, where a high resection rate is possible. As the relationship was with T stage rather than N stage it may be complimentary to PET scanning, which has only marginally better accuracy for T stage than CT scanning. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据