期刊
NEUROBIOLOGY OF AGING
卷 27, 期 7, 页码 941-945出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.05.021
关键词
Down syndrome; dementia; FISH; telomere shortening; metaphase; interphase
资金
- NIA NIH HHS [R01 AG 14673] Funding Source: Medline
- NICHD NIH HHS [R01 HD37425, P01 HD35897] Funding Source: Medline
Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female stud), participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status. (c) 2005 Elsevier Inc. All rights reserved.
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