期刊
CHEMISTRY & BIOLOGY
卷 13, 期 7, 页码 695-700出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2006.06.013
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资金
- NCI NIH HHS [R01 CA77042, R21 CA81088] Funding Source: Medline
- NIAID NIH HHS [R01 AI051360-01A1] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000501] Funding Source: Medline
Amphiphilic macromolecules containing a polystyrene-adherent peptide domain and a cell-repellent poly(ethylene glycol) domain were designed, synthesized, and evaluated as a cytophobic surface coating. Such cytophobic, or cell-repellent, coatings are of interest for varied medical and biotech nological applications. The composition of the polystyrene binding peptide domain was identified using an M13 phage display library. ELISA and atomic force spectroscopy were used to evaluate the binding affinity of the amphiphile peptide domain to polystyrene. When coated onto polystyrene, the amphiphile reduced cell adhesion of two distinct mammalian cell lines and pathogenic Staphylococcus aureus strains.
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