期刊
MOLECULAR PHARMACEUTICS
卷 3, 期 4, 页码 468-470出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp0500667
关键词
water-soluble manganese porphyrin; superoxide dismutase activity; signal peptide; mitochondrion; organella targeting
资金
- Japan Society for the Promotion of Science [14380409]
- Grants-in-Aid for Scientific Research [14380409] Funding Source: KAKEN
A new design of antioxidant, consisting of manganese (Mn) porphyrin and signal peptide for mitochondrial targeting, is reported. The resulting Mn-porphyrin-oligopeptide conjugate exhibited significant superoxide dismutase (SOD) activity and decomposed peroxynitrite (ONOO-). The new antioxidant caused the swelling of isolated mitochondria. By using the pH-sensitive drug carrier for intracellular delivery, furthermore, the new conjugate recovered the viability of lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. These results suggest that the Mn-porphyrin modified with signal peptide for mitochondrial targeting is promising for a new class of antioxidants.
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