期刊
ANNALS OF NEUROLOGY
卷 77, 期 1, 页码 177-182出版社
WILEY
DOI: 10.1002/ana.24298
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资金
- Swiss National Science Foundation [32003B-125504]
- Clinical Research Priority Program Sleep and Health of the University of Zurich
- Swiss National Science Foundation (SNF) [32003B_125504] Funding Source: Swiss National Science Foundation (SNF)
The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions. ANN NEUROL 2015;77:177-182
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