期刊
NUCLEIC ACIDS RESEARCH
卷 34, 期 -, 页码 W382-W384出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkl272
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资金
- NIGMS NIH HHS [R01 GM059708, GM59708] Funding Source: Medline
We present a bioinformatic web server ( SWAKK) for detecting amino acid sites or regions of a protein under positive selection. It estimates the ratio of non-synonymous to synonymous substitution rates (K-A/K-S) between a pair of protein-coding DNA sequences, by sliding a 3D window, or sphere, across one reference structure. The program displays the results on the 3D protein structure. In addition, for comparison or when a reference structure is unavailable, the server can also perform a sliding window analysis on the primary sequence. The SWAKK web server is available at http://oxytricha.princeton.edu/SWAKK/.
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