期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 169, 期 1, 页码 1-11出版社
ELSEVIER SCIENCE INC
DOI: 10.2353/ajpath.2006.060121
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资金
- NCI NIH HHS [R01 CA034432, R37 CA038173, R01 CA109481-02, R01 CA054807, R01 CA038173, R01 CA072001, R01 CA109481] Funding Source: Medline
Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.
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