期刊
CEREBRAL CORTEX
卷 16, 期 -, 页码 I26-I34出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhk011
关键词
cortical plate; neocortex; primate; subventricular zone
Regionalization of cell cycle kinetics of cortical precursors has been described in nonhuman primates and rodents indicating a fate map of areas as distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas 17 and 18, which show striking cytoarchitectonic differences, as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating 2 areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration, and tangential expansion.
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