期刊
ANNALS OF NEUROLOGY
卷 73, 期 2, 页码 309-315出版社
WILEY-BLACKWELL
DOI: 10.1002/ana.23793
关键词
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资金
- National Cancer Center Diversity Supplement Award [U01-CA141549]
- Department of Defense [W81XWH-10-1-0884]
- National Institute of Child Health and Human Development Center [P30 HD062171]
- National Institute of Neurological Disorders and Stroke
- National Institutes of Mental Health
- Neuroscience Blueprint Grant [NS057105]
- NIAAA
- NIGMS
- University of Florida
- NIH
- NCI
- MD Anderson Cancer Center
Children with neurofibromatosis type 1 (NF1) are prone to learning and behavioral abnormalities, including problems with spatial learning and attention. The molecular etiology for these deficits is unclear, as previous studies have implicated defective dopamine, cyclic adenosine monophosphate (cAMP), and Ras homeostasis. Using behavioral, electrophysiological, and primary culture, we now demonstrate that reduced dopamine signaling is responsible for cAMP-dependent defects in neuron function and learning. Collectively, these results establish defective dopaminergic function as a contributing factor underlying impaired spatial learning and memory in children and adults with NF1, and support the use of treatments that restore normal dopamine homeostasis for select individuals. ANN NEUROL 2013;73:309315
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