期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 32, 期 3, 页码 230-241出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2006.04.005
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资金
- NCRR NIH HHS [S10 RR017941] Funding Source: Medline
- NEI NIH HHS [EY13363] Funding Source: Medline
- NINDS NIH HHS [NS37159, NS44720, R29 NS037159] Funding Source: Medline
The architecture of dendritic arbors is a defining characteristic of neurons and is established through a sequential but overlapping series of events involving process outgrowth and branching, stabilization of the global pattern, and synapse formation. To investigate the roles of cadherins and beta 1-integrins in maintaining the global architecture of the arbor, we used membrane permeable peptides and transfection with dominant-negative constructs to disrupt adhesion molecule function in intact chick neural retina at a stage when the architecture of the ganglion cell (RGC) arbor is established but synapse formation is just beginning. Inactivation of beta 1-integrins induces rapid dendrite retraction, with loss of dynamic terminal filopodia followed by resorption of major branches. Disruption of N-cadherin-beta-catenin interactions has no effect; however, dendrites do retract following perturbation of the juxtamembrane region of N-cadherin, which disrupts N-cadherin-mediated adhesion and initiates a beta 1-integrin inactivating signal. Thus, developing RGC dendritic arbors are stabilized by beta 1-integrin-dependent processes. (c) 2006 Elsevier Inc. All rights reserved
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