期刊
TRENDS IN IMMUNOLOGY
卷 27, 期 7, 页码 328-335出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2006.05.006
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资金
- NIAID NIH HHS [U19 AI 056900, U19 AI056900] Funding Source: Medline
RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2-3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome.
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