期刊
CURRENT EYE RESEARCH
卷 31, 期 7-8, 页码 685-690出版社
INFORMA HEALTHCARE
DOI: 10.1080/02713680600801123
关键词
angiopoietin 2; genetic polymorphism; preterm infant; retinopathy of prematurity; vascular endothelial growth factor
Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF(-2578) and Ang2(-35) polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF(-2578) and Ang2(-35) and risk of ROP in preterm infants. The prevalence of VEGF(-2578) A allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).
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