期刊
MAGNETIC RESONANCE IN CHEMISTRY
卷 44, 期 -, 页码 S41-S50出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/mrc.1821
关键词
NMR; conotoxins; post-translational modification; chemical shifts; Conus; venom
Conotoxins are small conformationally constrained peptides found in the venom of marine snails of the genus Conus. They are usually cysteine rich and frequently contain a high degree of post-translational modifications such as C-terminal amidation, hydroxylation, carboxylation, bromination, epimerisation and glycosylation. Here we review the role of NMR in determining the three-dimensional structures of conotoxins and also provide a compilation and analysis of H-1 and C-13 chemical shifts of post-translationally modified amino acids and compare them with data from common amino acids. This analysis provides a reference source for chemical shifts of post-translationally modified amino acids. Copyright (C) 2006 John Wiley & Sons, Ltd.
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