期刊
PLOS COMPUTATIONAL BIOLOGY
卷 2, 期 7, 页码 816-823出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.0020096
关键词
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资金
- NIGMS NIH HHS [P01 GM068087, R37 GM34985, R37 GM034985, R01 GM034985] Funding Source: Medline
- NIMH NIH HHS [R01 MH044651, MH44651] Funding Source: Medline
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
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