期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 59, 期 1, 页码 51-64出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2006.01.003
关键词
cyclooxygenase; cancer; chemoprevention; targeted therapy; inflammation
The two isoforms cyclooxygenase-1 and -2 catalyze the initial step in the formation of prostaglandins in a variety of pathophysiological processes. More recently their role in carcinogenesis has become more evident. They seem to influence apoptosis, angiogenesis, and invasion, and play a role in the production of carcinogens. Usually, a high level of COX-2 expression is found in cancer cells. However, low COX-2 expression is observed in some cancers like prostate or breast cancer. This phenomenon is quite surprising and should influence on clinical trial designs.
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